Berberine

Berberine Synergy™ combines 400 mg of the plant alkaloid berberine (from Berberis aristata) along with 100 mg of alpha lipoic acid per capsule, in order to help support the management of healthy blood sugar levels and insulin sensitivity.* As downstream effects of these main actions, berberine may also help improve dyslipidemia, as well as other features of metabolic syndrome.

There are multiple mechanisms behind berberine’s influence on blood glucose control and insulin sensitivity.5 In diabetics with damaged pancreatic islet function, berberine's antioxidant promoting activity protected islet cells and promoted insulin secretion. Other mechanisms involved include the upregulation of insulin receptor (InsR) expression via increased InsR mRNA and protein expression via protein kinase C activation, increased GLUT1 expression which stimulated glucose uptake, inhibition of retinol binding protein-4, and promotion of GLP-1 secretion.3 In another study of diabetic and myocardial necrotic induced mice, berberine treatment exhibited significant cardio-protective and anti-diabetic effects by restoring CPK-MB, HbA1c, and blood glucose levels while favorably modulating lipid levels 6.

Suggested Use: Take 1 capsule twice daily with a meal, or as directed by your health-care practitioner